Scientific Publications

Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans
Atienzar F, Novik E, Gerets H, Parekh A, Delatour C, Cardenas A, MacDonald J, Yarmush M and Dhalluin S. Toxicology and Applied Pharmacology, 175 (2014) 44-61.

“Which models to use in Early Toxicology Assessment to detect Human Hepatotoxic Drugs?”
Atienzar F, slide presentation, ADME and Predictive Toxicology 2013. Barcelona, 11 April 2013.

Design and Application of Microfluidic Systems for In Vitro Pharmacokinetic Evaluation of Drug Candidates
TMaguire TM, Novik E, Chao P, Barminko J, Nahmias Y, Yarmush ML and Cheng KC. Current Drug Metabolism, 2009, 10.

A Microfluidic Hepatic Coculture Platform for Cell-based Drug Metabolism Studies
Novik E, Maguire TJ, Chao P, Cheng KC, Yarmush ML. Biochem Pharmacol. 2009 Nov 16.

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance.
Kidambi S, Yarmush RS, Novik E, Chao P, Yarmush ML, Nahmias Y. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15714-9.
(view/download pdf)

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
P. Chao, T. Maguire, E. Novik, K.-C. Cheng and M.L. Yarmush Biochem Pharmacol. 2009 May 19.
(view/download pdf)

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers.
Tatosian DA, Shuler ML Biotechnol Bioeng. 2009 May 1;103(1):187-98
(view/download pdf)

Real-time fluorescence detection of multiple microscale cell culture analog devices in situ.
Oh TI, et al. Cytometry A. 2007 Oct;71(10):857-65
(view/download pdf)

Incorporation of 3T3-L1 cells to mimic bioaccumulation in a microscale cell culture analog device for toxicity studies.
Viravaidya K, et al. Biotechnol Prog. 2004 Mar-Apr;20(2):590-7
(view/download pdf)

An In Vivo-Surrogate Assay Platform for Cell-based Studies
Baxter GT, Freedman RM American Biotechnology Laboratory, February, 2004
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The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors.
Sin A, et al. Biotechnol Prog. 2004 Jan-Feb;20(1):338-45
(view/download pdf)

Development of a microscale cell culture analog to probe naphthalene toxicity.
Viravaidya K, et al. Biotechnol Prog. 2004 Jan-Feb;20(1):316-23
(view/download pdf)