Video: Les Benet on Hurel
Dr. Benet’s July, 2013 presentation to The Boston Society, “Hepatic Artificial Tissue Constructs Affording Interspecies Comparison of DMPK Endpoints in Human, Rat and Dog,” reviews and compares 21-day characterization data of the HµRELhumanTM, HµRELdogTM, and HµRELratTM primary cell-based hepatic co-cultures, demonstrating the products’ abilities to correlate in vitro with in vivo results and to model interspecific differences of response to reference compounds known to clear and to generate primary and secondary metabolites differentially in different species in vivo. The running time of the presentation is approximately seventeen minutes.



HµRELToxTM
multi-readout, repeat-dose
DILI screening
DILI screening

Hurel microlivers afford better prediction than 3D

Toxicology Research
HµRELviralTM
Long-enduring infectious liver disease platform
Time-Based
Toxicity Ratios*
A new marker for hepatotoxic chronicity

TAAP
*patent pending
HµRELfluxTM
a new, patent-pending
efflux transport
assay method
DMPK
Superior intrinsic clearance
and biotransformation of
low-turnover drugs

DMD